Scientists find a unique mutation in centenarians. What is known?

These conclusions were drawn from genome analysis of “supercentenarians” – individuals over eighty who have retained sharp minds and good memories.

In a large-scale study, scientists compared the genetic data of 1,600 “supercentenarians” with that of 17,000 peers diagnosed with Alzheimer’s disease or showing typical age-related memory impairment.

The analysis revealed significant differences in the APOE gene, long known for its link to dementia risk. Among “supercentenarians,” the risky APOE4 mutation, which increases the likelihood of the disease, was found 68% less often, while the protective APOE2 variant was 28% more frequent than in other healthy individuals of the same age group.

“We were able to uncover how variations of the APOE gene affect the probability of becoming a centenarian with a strong memory,” explained VUMC associate professor Leslie Gaynor.

This discovery underscores that in-depth study of the genomes of people resistant to age-related brain diseases can reveal previously unknown protective strategies and therapeutic targets that could delay or even halt the progression of dementia, writes OSN.